STUDY OF HUMAN PHONATION WITH ATTENTION ON SUB-GRID SCALE TURBULENCE MODELS AND INITIALIZATION EFFECTS



Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors

Proprotein convertases are enzymes that proteolytically cleave protein precursors in the secretory pathway to yield functional proteins.Seven mammalian subtilisin/Kex2p-like proprotein convertases have been identified: furin, PC1, PC2, PC4, PACE4, PC5 and PC7.The binding pockets of all seven proprotein convertases are evolutionarily conserved and h

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